When using Excel 2010 or a later version you notice right away that the Print Preview is completely different than in Excel 2007. If you click the Page Setup tool, Excel displays the Page Setup dialog box which has all the tools available for use. (You can also display Print Preview by pressing Ctrl+F2 or by pressing Ctrl+P and then clicking the Preview button.) Regardless of how you get to the Print Preview screen, the normal tabs of the ribbon are gone and only a Print Preview tab remains.

When using Excel 2007, you can access Print Preview by clicking the Office button, then clicking Print | Print Preview. I had a few other ExcelTips subscribers indicate that the condition occurs when Page Setup is accessed through Print Preview, but I couldn't get that to occur, either. In Excel 2007, Excel 2010, Excel 2013, Excel 2019, and Excel in Office 365 the Page Setup tools are always available. Try as I might, I cannot get this situation to occur on any of my test systems.

He wonders why they would be disabled and what he can do to make them available.

Ali notes that on his copy of Excel the tools in the Page Setup group of the Page Layout tab of the ribbon (Margins, Orientation, Print Area, etc.) are disabled.

Excel ribbon is greyed out